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Criteria: SO-TI Found: 31 cases
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Case 1 - ecp24, Soft Tissue and Bone Pathology
Presented by: Carlos E. de Andrea, Pamplona, Spain

A 41-year-old man was referred to our institution with a history of swelling and pain in the left upper leg. A rapid increase in size had been noted over the preceding 2 months. A non-pulsatile, painful mass was found in the left proximal femur. There was no evidence of neurological compromise.
Slide 1B_12_100B_12_100_1B_12_100_2
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Case 2 - ecp24, Soft Tissue and Bone Pathology
Presented by: Albert J.H. Suurmeijer, Groningen, Netherlands

The case concerns a 21-year-old female who had pain of her right foot for several months.With MRI a 5 x 1,5 cm soft tissue tumor was seen in the sinus tarsi (between talus and calcaneus). With H&E, IHC and molecular biology a specific sarcoma was diagnosed. A lower leg amputation was performed. The slide represents a cross section through the tumor in the sinus tarsi.
grossfig1fig8fig11fig13fig14
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Case 3 - ecp24, Soft Tissue and Bone Pathology
Presented by: Albert J.H. Suurmeijer, Groningen, Netherlands

59-year-old male with a slow growing tumor in the deep soft tissue of the upper arm (m.deltoideus)..
macroscopyfig1fig2fig3fig4fig5EMA1
EMA2CD34
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Case 4 - ecp24, Soft Tissue and Bone Pathology
Presented by: Zoltan Sapi, Budapest, Hungary

55 year old female. 2 years ago a rectal tumor was operated on. Recently, a 2x3 cm subcutaneus nodule was removed from her left forearm.
case4 HE1case4 HE2case4 HE3case4 SMAcase4 H-Caldesmon
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Case 5 - ecp24, Soft Tissue and Bone Pathology
Presented by: Zoltan Sapi, Budapest, Hungary

43 year old female presented with multiple pulmonary nodules measuring from 1 to 7 cm. Metastasectomy was performed from right pulmonary lobes. 8 years ago a hysterectomy was carried out due to myomas.
case5 HE1case5 HE2case5 HE3case5 SMAcase5 desmincase5 H-Caldesmoncase5 Ki67
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Case 6 - ecp24, Soft Tissue and Bone Pathology
Presented by: Jean-Michel Coindre, Bordeaux, France

• 21 year-old man with a pelvic tumor (December 1998)
• MRI: 12 cm tumor with involvement of bone and muscles
• Surgical biopsy
SlideSeminarCase6aSlideSeminarCase6bSlideSeminarCase6Prague2012Case6-CD99
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Case 1 - ecp23, Soft Tissue and Bone Pathology
Presented by: Alexander Lazar, Houston, Texas, United States

The patient is a female aged 50 who presented with a recently noticed, painful right proximal thigh/groin mass. A CT-scan of the region revealed a 15 cm enhancing mass in the right thigh/groin region with right inguinal and iliac lymphadenopathy. Chest imaging failed to reveal metastatic disease and additional staging studies were negative. On physical exam, there was a relatively indistinct, mildly tender thigh/groin and palpable groin lymphadenopathy that was firm but non-tender. After an initial diagnostic biopsy, the lesion was excised. Images from the excision specimen are provided for review.
Slide 1Slide 2Slide 3
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Case 2 - ecp23, Soft Tissue and Bone Pathology
Presented by: Maureen O’Sullivan, Dublin, Ireland

Our patient presented at age 6 months with a mass protruding from her vagina. Biopsy was taken and a representative section is provided [see Slide 1]. Imaging revealed a vaginal mass and separate para-aortic lesion together with enlarged bilateral iliac nodes. Following 5 months of chemotherapy, she had a macroscopic complete resection of the pelvic/vaginal mass, including a para-aortic abdominal lesion. Histology showed viable tumour cells accounting for at least 50% of the resected tumour [see Slides 2a, b, c]. Chemotherapy was intensified as a result of this poor response, but she developed progressive recurrent abdomino-pelvic tumour requiring further biopsy four months later. Histology at this time showed somewhat different histology [see Slide 3]. Therapy was altered to include cisplatin and etoposide. Progression of the abdomino-pelvic tumour was confirmed by fine-needle aspiration biopsy of an umbilical mass at 12 months post-initial diagnosis and subsequent management was with palliative intent until the patient’s demise three months later.
Slide 1Slide 2aSlide 2bSlide 2cSlide 3
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Case 3 - ecp23, Soft Tissue and Bone Pathology
Presented by: Nicolas de Saint Aubain, Brussels, Belgium

A 36-year-old patient presented with a 4cm, slowly-growing, painless, subcutaneous right ankle mass.
Slide 1 - Rescanning
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Case 4 - ecp23, Soft Tissue and Bone Pathology
Presented by: G. de Pinieux, Tours, France

A 31-year-old woman presented with a right hip pain. X-rays and MRI revealed an expansive lytic tumor of the acetabulum of 5 cm in diameter, with cortical disruption.

On the T2-weighted MR image, the intensity of the tumor was globally high. Small foci exhibited however higher intensity, suggesting the presence of two distinct components in the tumor. A peri-lesional oedema was also observed.

A percutanous biopsy was performed. The sample obtained was insufficient for establishing a definite diagnosis. It showed a small area of a giant cell rich lesion with a benign appearance, that was interpreted as a possible giant cell tumor of bone.

In the absence of evidence of malignancy, a curettage of the tumor was performed.
Slide 1MRIHES 1HES 2HES 3HES 4HES 5
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