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Presented by: Ales Ryska, Hradec Kralove, Czech Republic
A 49-year-old female with non-palpable breast tumor in the upper outer quadrant of her right breast diagnosed on screening mammography. The tumor had 12 mm in largest diameter and showed an unsharp margin. Attempts for fine needle aspiration cytology and core cut biopsy were both non-diagnostic. Therefore, breast conserving surgery with removal of the specimen 40x30x30 mm was performed, material was send for pathological examination. The tumor was solid, whitish, uncircumscribed, localized close to the nearest resection margin (<1 mm). After the final diagnosis was made, partial mastectomy and axillary lymph nodes dissection followed by radiation therapy and 6 cycles of systemic adjuvant chemotherapy was done. Ten years after initial diagnosis, the patient is disease free and well. |
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| Virtual slide HE | p63 | CD10 | p53 | CK18 |
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Presented by: Erika Resetkova , Houston, United States
A 29-year-old woman with palpable mass located in the posterior aspect of the right breast and small pea-sized peripheral nodules. US-guided core needle biopsy of the larger posterior mass was performed. On a subsequent excisional specimen, grossly two lobulated masses (1.3 and 0.8 cm in greatest dimension) were identified. Tumor was negative for breast prognostic/predictive markers. Sentinel lymph nodes were also negative. The patient is disease free ten years after initial diagnosis.
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| Slide 1 | H&E, low power magnification, 4x | H&E, high power magnification (20x) |
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Presented by: Saudade André, Lisboa, Portugal
Woman, post-menopausal, 56 years, presented with a palpable lump with 5cm and with skin retraction, in the right breast. No personal or familial antecedents of breast pathology were documented. A biopsy was performed.
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Presented by: Gábor Cserni, Kecskemét & Szeged, Hungary
• 47-year-old female with palpable nodule in the right breast, more likely to be benign on the basis of physical examination and mammography.
• R3 U4 (Slightly irregular,14x11 mm)
• US-guided FNAC: C5 - could be correlated with imaging
• Breast conserving surgery and sentinel lymph node biopsy - the slide is from the excision specimen.
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| Slide 1 | PAS-AB | PAS-AB x400 | CK5 x400 |
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Presented by: Isabel Amendoeira, Porto, Portugal
77 year-old woman presenting with a well defined nodule on the central portion of the right breast, BI-RADS 5. A core-needle biopsy was performed followed by a mastectomy with sentinel node biopsy.
Macroscopy: a 27mm circumscribed tumour, whitish and compact with some microcysts, 30mm from the nipple.
Histology: the tumour has an expansive growing pattern mainly surrounded by fibrous tissue and it is composed by solid and glandular/pseudoglandular components. The cells are small, myoepithelial and epithelial cells, polarized around two types of spaces - glandular or pseudolumina. The true glandular spaces are surrounded by luminal cells and contain neutral mucin (PAS positive); the pseudolumina are stromal spaces filled by cylinders of hyaline material, surrounded by basal/myoepithelial cells; these spaces stain for Alcian Blue and collagen IV. The cells in the solid areas and around the cylinders stain for p63, smooth-muscle actin as well as for high-molecular-weight keratins. Cells around the lumina stain for low-molecular-weight keratin (for example keratin 7), as well as for CD117. On the cystic component, squamous metaplasia can be observed. Focally mainly in the solid areas the cells are bigger with evident nucleoli and the mitotic index is higher. Necrotic foci can be observed.
The tumour is negative for ER, PR and HER2.
The two sentinel nodes removed were negative.
The patient had no additional treatment and at one year of follow-up is alive with no evidence of disease.
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Presented by: Zsuzsanna Varga, Zurich, Switzerland
A 26 years-old patient presented with a circumscribed mass lesion of the breast. The lesion was approximately 15 mm on ultrasonography and on mammography. Surgical excision of the lesion was performed without preoperative core- or vacuum biopsy clarification of the lesion.
Stains: HE, S100, Coll IV, Calponin, ER |
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| HE low-power | HE | HE | HE high power | S100 | Collagen type IV | Calponin |
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| p63 | ER |
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Presented by: Clive Wells, London, United Kingdom
A 65 year old woman presented with a 6-8 week history of a painful lump above the left nipple, clinically suspicious of carcinoma but with a history of chest trauma 1 year previously. Cytology taken showed a cellular sample with numerous large cells, some containing phagocytosed material, presumed to be haemosiderin amidst droplets of fat. Occasional clusters of benign duct epithelium and occasional multinucleated cells. Features unusual but consistent with fat necrosis. Core biopsy taken.
Virtual slide of core biopsy and immunohistochemistry.
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| Slide 1 | y1 immuno_1 | y1 immuno_2 | y1 immuno_3 | y1 immuno_4 |
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Presented by: Malcolm Hayes, Vancouver, Canada
• 69 year-old woman presented with abnormal calcifications at the 10.00 o’clock position of the right breast, 8cm from the nipple on screening mammogram. These were suspicious for DCIS.
• Abnormal calcifications were also seen at the 6 o’clock position of the left breast 3 cm. from the nipple. These were thought to represent a benign lesion such as sclerosing adenosis.
• Core biopsies were performed under imaging guidance.
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| Slide 1 | Hayes-Core biopsy Slide 1 HE | Hayes1-Slide 2 (HE) | Hayes1-Slide 3 (HE) | Hayes1-Slide 4 (HE) | Hayes1-Slide 5 (HE) |
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Presented by: James de Gaetano, Valletta, Malta
• 56 year old woman with screen detected mammographic abnormality (BIRADS 3)
• No mass was palpable.
An Ultrasound showed a hypoechoeic lesion and biopsy was advised
• Two core biopsies were subsequently obtained
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| Slide 1 | 32972-11iii | 32972-11ix | 32972-11-Keratin14ii | 32972-11vii | 32972-11xix | 33877-11-CD3 ii |
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| 33877-11-CD20 i | 33877-11-E-cadherin ii | 33877-11ii | 33877-11-keratin 7iv | 33877-11xii | 33877-11xvi | 33877-11xviii |
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Presented by: Alena Skalova, Pilsen, Czech Republic
53-year-old woman with no remarkable medical history presented with painful left breast mass that had enlarged during the past year. Physical examination revealed a palpable, large, ill-defined lesion in the central area of left breast. No nipple discharge was noted. Surgical excision specimen consisted of 7x 5.5x 2.5 cm fibrofatty tissue with ill-defined irregular pink-tan area that extended to the surgical margins and contained many microcystic spaces and dilated ducts filled with viscous, translucent mucoid material.
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| Slide 1 | slide 1:HE | slide 2: HE | slide 3: HE | slide 4:HE |
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